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- Title
Molecular Aspects of Cellular Dysfunction in Alzheimer's Disease: The Need for a Holistic View of the Early Pathogenesis.
- Authors
Merlo, Sara; Spampinato, Simona Federica; Lim, Dmitry
- Abstract
The initial neuronocentric view of AD etiology was fully replaced by the evidence that the glial counterpart is equally involved in disease pathogenesis. Reaching this goal will require further understanding of the molecular complexity in the early time-window of AD pathogenesis, including cell-specific molecular dysfunctions that may, in turn, impact the cross-talk between different CNS cell types. In conclusion, evidence from previous decades suggests that the preclinical and prodromal phases of AD pathogenesis represent the only window of opportunity for the early diagnosis and development of preventive or disease-modifying therapies. Alzheimer's disease (AD) is the most common cause of dementia in the elderly, a socio-economic burden destined to worsen with increased population aging [[1]].
- Subjects
ALZHEIMER'S disease; TAU proteins; PATHOGENESIS; RETINAL ganglion cells
- Publication
Biomolecules (2218-273X), 2021, Vol 11, Issue 12, p1807
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom11121807