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- Title
Nitric oxide-donating NSAIDs.
- Authors
Tam, S. W.; Saha, J. K.; Garvey, D. S.; Schroeder, J. D.; Bandarage, U.; Dong, Q.; Janero, D. R.; Chen, L.; Shelekhin, T. E.; Glavin, A.; Letts, L. G.
- Abstract
Focuses on the role of nitric oxide (NO) in maintaining gastric mucosal integrity which helps in the prevention of non-steroidal anti-inflammatory drug (NSAID)-induced gastric damage. Approaches to NO administration against the gastric toxicity of NSAID; Administration of S-nitrosoglutathione in combination with high dose of piroxicam; Synthesis of NSAID with NO-donating moiety.
- Subjects
NITRIC oxide; NONSTEROIDAL anti-inflammatory agents; GASTRIC mucosa; PIROXICAM; BIOCHEMICAL mechanism of action; DRUG side effects; PHYSIOLOGY
- Publication
Inflammopharmacology, 1999, Vol 7, Issue 3, p319
- ISSN
0925-4692
- Publication type
Article