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- Title
Rare Anemias: Are Their Names Just Smoke and Mirrors?
- Authors
Simionato, Greta; van Wijk, Richard; Quint, Stephan; Wagner, Christian; Bianchi, Paola; Kaestner, Lars
- Abstract
For most pathophysiologial conditions RBC morphology in (capillary) flow are not investigated, which is a so far missed diagnostic potential but at the same time is not in favor of naming anemias after RBC shapes in stasis. In contrast, many cells look like spherocytes from one direction (leftmost view in all boxes) but the other faces reveal different morphologies, such as mushroom-shaped cells, stomatocytes or other irregular-shaped cells (all light colored boxes) representing "pseudo spherocytes." Keywords: rare anemias; red cell morphology; hereditary spherocytosis; dehydrated stomatocytosis; hereditary xerocytosis; Gárdos channelopathy EN rare anemias red cell morphology hereditary spherocytosis dehydrated stomatocytosis hereditary xerocytosis Gárdos channelopathy 1 5 5 06/12/21 20210610 NES 210610 Introduction Numerous anemias and even neurodegenerative diseases are named after the predominant red blood cell (RBC) shape observed by microscopy - within this paper we refer to this as RBC morphology. Spherocyte Numbers in Hereditary Spherocytosis - Comparison Between 2D and 3D Images A recent study investigated the use of an artificial neural network to automatically recognize RBC shapes, proposing that the detailed 3D analysis may even identify the specific genetic defect causing a particular rare anemia (Simionato et al., [42]).
- Subjects
ANEMIA; ERYTHROCYTES; CELL morphology; SICKLE cell anemia; BIOLOGICAL transport; GLUCOSE-6-phosphate dehydrogenase deficiency; DEHYDRATION
- Publication
Frontiers in Physiology, 2021, Vol 12, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2021.690604