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- Title
Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.
- Authors
Xiaojin WU; Fanping YANG; Shengan CHEN; Hao XIONG; Qinyuan ZHU; Xudong GAO; Qinghe XING; Xiaoqun LUO
- Abstract
DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. All the patients had skin eruption, 83% had liver involvement, and ≤10% had other organ involvement. Mean cost of hospitalization was US$5,511 ± 3,050. The 3 most common causative agents were allopurinol (18/52; 35%), salazosulphapyridine (11/52; 21%) and carbamazepine (5/52; 10%). HLA-B*5801 and HLA-B*1302 were associated with allopurinol-induced DRESS. HLA-B*1301 was related to salazosulphapyridine-induced DRESS. The mortality rate was 6% (3/52). Epstein-Barr virus DNA was found in 10 patients (19%) and indicated a poor prognosis. Human herpes virus 6 DNA was detected in 17 patients (33%) and was associated with autoimmune sequelae. Due to its high medical cost and sometimes poor prognosis, prevention of DRESS should be a high priority.
- Subjects
DRESS syndrome; EOSINOPHILIA; ALLOPURINOL; CARBAMAZEPINE; HERPESVIRUSES; DISEASE complications; THERAPEUTICS
- Publication
Acta Dermato-Venereologica, 2018, Vol 98, Issue 4, p401
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2867