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- Title
Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation.
- Authors
Dai, Lan; Wang, Chen; Song, Keqi; Wang, Wenjing; Di, Wen
- Abstract
Background: Adipocytes, active facilitators of epithelial ovarian cancer (EOC) growth, have been implicated in the link between obesity and EOC. However, the current understanding of the mechanisms underlying adipocyte-induced EOC cell proliferation remains incomplete. Results: We provide the first evidence showing that sphingosine kinase (SphK) 1 is critical for adipocyte-induced EOC cell proliferation. Adipocytes are capable of activating SphK1, which then leads to extracellular signal-regulated kinase (ERK) phosphorylation. Moreover, adipocyte-induced SphK1 activation is ERK dependent. Furthermore, sphingosine 1-phosphate receptor (S1PR) 1 and S1PR3, key components of the SphK1 signalling pathway, participate in adipocyte-mediated growth-promoting action in EOC cells. Conclusions: Our study reveals a previously unrecognized role of SphK1 in adipocyte-induced growth-promoting action in EOC, suggesting a new target for EOC therapy.
- Subjects
OVARIAN epithelial cancer; CANCER cell proliferation; SPHINGOSINE kinase; FAT cells; CELL proliferation
- Publication
Journal of Ovarian Research, 2021, Vol 14, Issue 1, p1
- ISSN
1757-2215
- Publication type
Article
- DOI
10.1186/s13048-021-00815-y