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- Title
Comparative metabolism of o-toluidine by the abalone (Haliotis rufescens) and flatfish (Platichthys stellatus).
- Authors
Knezovich, John P.; Crosby, Donald G.
- Abstract
Abalone and flatfish excreted 2-nitrosotoluene and N-acetyl- o-toluidine, respectively, as the only biotransformation products of o-toluidine. The elimination of o-toluidine over a 4-h period was high for both species (greater than 80%), but the total extent of metabolism was low (less than 2%). A Sprague-Dawley rat was used to compare the metabolic pathways typically found in mammals with those found in the marine organisms. Metabolism of o-toluidine by the rat was extensive (greater than 95%), and ring-hydroxylated conjugates were rapidly eliminated. The metabolic capabilities of terrestrial vertebrates are more extensive than those found in aquatic organisms and may reflect the greater need for water conservation in terrestrial species. Aquatic organisms such as molluscs may not be at a disadvantage, however, because many such compounds are likely to be eliminated by passive diffusion.
- Publication
Environmental Toxicology & Chemistry, 1986, Vol 5, Issue 4, p387
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1897/1552-8618(1986)5[387:cmoobt]2.0.co;2