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- Title
Genome-wide association studies and Crohn’s disease.
- Authors
Lee, James C.; Parkes, Miles
- Abstract
The development of genome-wide association scanning (GWAS) has revolutionized the search for genetic loci associated with complex diseases. Crohn’s disease (CD), together with ulcerative colitis, has been a principal beneficiary of this technology with a recent meta-analysis from the International IBD Genetics Consortium increasing the number of confirmed CD susceptibility loci to 71. When one considers that prior to the development of GWAS only three susceptibility loci had been identified, the degree of progress becomes obvious. In this article we will summarize the principal discoveries that have been made in CD genetics and explain how these have contributed to our improved understanding of disease pathogenesis.
- Subjects
GENETICS of Crohn's disease; HUMAN genome; ULCERATIVE colitis; META-analysis; PATHOGENIC microorganisms
- Publication
Briefings in Functional Genomics, 2011, Vol 10, Issue 2, p71
- ISSN
2041-2649
- Publication type
Article
- DOI
10.1093/bfgp/elr009