We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Skullcapflavone II Alleviates Lipopolysaccharide-Induced Apoptosis and Inflammation in WI-38 Cells.
- Authors
Donglian Wang; Guoyong Hu; Lidong Zhao; Pengcheng Xing; Minjie Zhou; Chao Han
- Abstract
The role of skullcapflavone II in pneumonia was investigated using lipopolysaccharide treated human lung fibroblasts WI-38 cells as a model. Lipopolysaccharide treatment led to decreased cell viability, increased cell apoptosis and inflammation. Exposure of these lipopolysaccharide-treated cells to skullcapflavone II resulted in amelioration of cytotoxic effects of the lipopolysaccharide. The reduced IκBα expression and enhanced p-IκBα and p-p65 in WI-38 cells caused by the lipopolysaccharide treatment were reversed by skullcapflavone II. In conclusion, skullcapflavone II exerts antiapoptotic and anti-inflammatory effects on lipopolysaccharide-induced WI-38 through inhibition of NF-κB pathway.
- Subjects
LIPOPOLYSACCHARIDES; PNEUMONIA; FLOW cytometry; CYTOKINES; FIBROBLASTS; CELL culture; STAINS &; staining (Microscopy); INFLAMMATION; ANTI-inflammatory agents; FLUOROIMMUNOASSAY; WESTERN immunoblotting; APOPTOSIS; T-test (Statistics); FLAVONES; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; CELL lines; MOLECULAR structure; DATA analysis software
- Publication
Current Topics in Nutraceutical Research, 2022, Vol 20, Issue 3, p478
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.20:478-483