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- Title
Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review.
- Authors
Contardi, Marco; Lenzuni, Martina; Fiorentini, Fabrizio; Summa, Maria; Bertorelli, Rosalia; Suarato, Giulia; Athanassiou, Athanassia
- Abstract
Alterations of skin homeostasis are widely diffused in our everyday life both due to accidental injuries, such as wounds and burns, and physiological conditions, such as late-stage diabetes, dermatitis, or psoriasis. These events are locally characterized by an intense inflammatory response, a high generation of harmful free radicals, or an impairment in the immune response regulation, which can profoundly change the skin tissue' repair process, vulnerability, and functionality. Moreover, diabetes diffusion, antibiotic resistance, and abuse of aggressive soaps and disinfectants following the COVID-19 emergency could be causes for the future spreading of skin disorders. In the last years, hydroxycinnamic acids and derivatives have been investigated and applied in several research fields for their anti-oxidant, anti-inflammatory, and anti-bacterial activities. First, in this study, we give an overview of these natural molecules' current source and applications. Afterwards, we review their potential role as valid alternatives to the current therapies, supporting the management and rebalancing of skin disorders and diseases at different levels. Also, we will introduce the recent advances in the design of biomaterials loaded with these phenolic compounds, specifically suitable for skin disorders treatments. Lastly, we will suggest future perspectives for introducing hydroxycinnamic acids and derivatives in treating skin disorders.
- Subjects
HYDROXYCINNAMIC acids; ACID derivatives; IMMUNOREGULATION; COVID-19 pandemic; SKIN diseases; PHENOLS
- Publication
Pharmaceutics, 2021, Vol 13, Issue 7, p999
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics13070999