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- Title
Efficient generation of constrained block allocation sequences.
- Authors
Salama, Ibrahim; Ivanova, Anastasia; Qaqish, Bahjat
- Abstract
Selection bias is a potential problem, especially in trials where blinding is not possible. Randomization with a constrained block of large size provides better protection from selection bias than using a sequence of blocks of small size with the same maximum imbalance. We propose an algorithm that efficiently generates constrained block allocation sequences, and we describe two clinical trials in which such a constrained randomization was used. Copyright © 2007 John Wiley & Sons, Ltd.
- Publication
Statistics in Medicine, 2008, Vol 27, Issue 9, p1421
- ISSN
0277-6715
- Publication type
Article
- DOI
10.1002/sim.3014