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- Title
Loss of Programmed Cell Death 4 Expression Marks Adenoma-Carcinoma Transition, Correlates Inversely With Phosphorylated Protein Kinase B, and Is an Independent Prognostic Factor in Resected Colorectal Cancer.
- Authors
Mudduluru, Giridhar; Medved, Fabian; Grobbolz, Rainer; Jest, Camela; Gruber, Anette; Leupold, Joerg H.; Post, Stefan; Jansen, Aaron; Colburn, Nancy H.; Allgayer, Heike
- Abstract
The article focuses on a study on programmed cell death 4 (Pdcd4) as a diagnostic marker in the adenoma-carcinoma sequence. The study on Pdcd4 was performed in a series of several patients with colorectal cancer. The levels of Pdcd4 protein expression in resected tumors and corresponding normal tissues are determined. To support the regulation of Pdcd4 by data in a subset of resected tumors, Akt/phosphorylated Akt staining is performed. The levels of Pdcd4 expression in normal tissues, colonic adenomas and colorectal cancer are compared.
- Subjects
CELL death; ADENOMA; COLON cancer; TUMORS; TISSUES
- Publication
Cancer (0008543X), 2007, Vol 110, Issue 8, p1697
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.22983