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- Title
C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma.
- Authors
TEKCAN, Akın; GÜMÜŞAY, Özge; NURSAL, Ayşe Feyda; YİĞİT, Serbülent; YILDIZ, Serkan; TÜMER, Mehmet Kemal
- Abstract
OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial role in the regulation of the cell cycle. Mutations of the p53 gene havean important role in OSCC carcinogenesis. In this study, we aimed to evaluate the C-deletion mutation in exon 4 codon 63 of p53 gene in Turkish patients with OSCC. METHODS A total of 60 subjects were enrolled in this study, 30 patients with a pathologic diagnosis of OSCC and 30 cases of age and sex-matched healthy controls. Genotyping was performed for all individuals using polymerase chain reaction (PCR) analysis. RESULTS The findings showed that the distribution of p53 exon 4 codon 63 C-deletion was significantly different between patient group and control group (p=0.000). It was detected that all patients had C-deletion mutation in exon 4 codon 63 of p53. CONCLUSION Our results suggest that C-deletion in exon 4 codon 63 deletion of the p53 gene may play a role in the pathogenesis of human OSCC in a Turkish cohort.
- Subjects
TURKEY; AGE distribution; TUMOR suppressor genes; MOUTH tumors; GENETIC mutation; POLYMERASE chain reaction; RISK assessment; SEX distribution; SQUAMOUS cell carcinoma; GENOTYPES; DISEASE risk factors
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2020, Vol 35, Issue 2, p163
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjo.2019.2092