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- Title
TRAF-2/ASK-1/p38/NF-ϰB pathways in normal prostate, benign prostatic hyperplasia and prostatic cancer.
- Authors
BOURAOUI, Yosra; BEN JEMAA, Awatef; SALLAMI, Sataa; BEN RAIS, Nawfel; ROYUELA, Mar; OUESLATI, Ridha
- Abstract
This study was designed in order to analyze the expression of the transduction pathways TRAF-2/ASK-1/MEK-6/Pp38 and NF-ϰB/p65, involved in the proliferation/apoptosis equilibrium in normal and pathological conditions. The study was carried out in 5 Normal Prostates (NP), 24 Benign Prostate Hyperplasia (BPH) and 19 Prostate Cancers (PC). Immunohistochemical and Western blotting analysis was performed. Western Blotting analysis revealed immunoexpression of TRAF-2, ASK-1, MEK-6 and Pp38 in BPH and PC. MEK-6 and NF-ϰB/p65 were absent in NP. Immunohistochemical analysis showed significant weak optical density to ASK-1 in PC compared to NP and BPH. Optical densities to MEK-6 and NF-ϰB/p65 were significantly intense in PC. p38 activation in prostate cancer could have apoptotic and proliferation role depending on the activation of its upstream and downstream component.
- Subjects
GENETIC transduction; PROSTATE cancer; BENIGN prostatic hyperplasia; WESTERN immunoblotting; APOPTOSIS
- Publication
Journal of Biological Research, 2012, Vol 18, p301
- ISSN
1790-045X
- Publication type
Article