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- Title
Prediction of methicillin-resistant Staphylococcus aureus in patients with non-nosocomial pneumonia.
- Authors
Won Jai Jung; Young Ae Kang; Moo Suk Park; Seon Cheol Park; Ah Young Leem; Eun Young Kim; Kyung Soo Chung; Young Sam Kim; Se Kyu Kim; Joon Chang; Ji Ye Jung; Jung, Won Jai; Kang, Young Ae; Park, Moo Suk; Park, Seon Cheol; Leem, Ah Young; Kim, Eun Young; Chung, Kyung Soo; Kim, Young Sam; Kim, Se Kyu
- Abstract
<bold>Background: </bold>Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as an important cause of not only hospital acquired pneumonia, but also non-nosocomial pneumonia. However, the risk factors for non-nosocomial MRSA pneumonia are not clearly defined. Our objective was to identify risk factors at admission that were associated with non-nosocomial MRSA pneumonia.<bold>Methods: </bold>We evaluated 943 patients admitted to a university-affiliated hospital with culture-positive bacterial pneumonia developed outside the hospital from January 2008 to December 2011. We compared the clinical characteristics between MRSA and non-MRSA pneumonia, and identified risk factors associated with MRSA pneumonia.<bold>Results: </bold>Of 943 patients, MRSA was identified in 78 (8.2%). Higher mortality was observed in MRSA than in non-MRSA patients (33.3% vs. 21.5%; P = 0.017). In a logistic regression analysis, MRSA pneumonia was observed more frequently in patients with a previous history of MRSA infection (OR = 6.05; P < 0.001), a PSI score ≥120 (OR = 2.40; P = 0.015), intravenous antibiotic treatment within 30 days of pneumonia (OR = 2.23; P = 0.018). By contrast, non-MRSA pneumonia was observed more often in patients with a single infiltrate on chest radiography (OR = 0.55; P = 0.029).<bold>Conclusions: </bold>Anti-MRSA antibiotics could be considered in hospitalized non-nosocomial patients with several risk factors identified herein. The presence or absence of these factors would provide useful guidance in selecting initial empirical antibiotics.
- Subjects
METHICILLIN-resistant staphylococcus aureus; STAPHYLOCOCCUS aureus; DRUG resistance in bacteria; PNEUMONIA; ANTIBIOTICS; ANTI-infective agents
- Publication
BMC Infectious Diseases, 2013, Vol 13, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/1471-2334-13-370