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- Title
The attachment disorders of muscle: failure to carb-load.
- Authors
McNally, Elizabeth M.
- Abstract
Dystroglycan is a prominent cell surface protein that mediates attachment to the extracellular matrix. Although broadly expressed, glycosylated dystroglycan is critically important for muscle cell adherence to its surrounding matrix. A subgroup of muscular dystrophies, which often manifest in infancy, is associated with reduced glycosylation of dystroglycan. In this issue of the JCI, Beedle et al. used conditional gene targeting of Fktn, the gene responsible for Fukuyama congenital muscular dystrophy, to investigate a developmental requirement for glycosylation of dystroglycan.
- Subjects
ATTACHMENT disorder; MUSCLE diseases; DYSTROGLYCAN; CARBOHYDRATE loading for exercise; GLYCOSYLATION; EXTRACELLULAR matrix; MUSCLE cells; CELL adhesion
- Publication
Journal of Clinical Investigation, 2012, Vol 122, Issue 9, p3046
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI65483