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- Title
Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis.
- Authors
Cirer-Sastre, Rafel; Legaz-Arrese, Alejandro; Corbi, Francisco; George, Keith; Nie, Jinlei; Carranza-García, Luis Enrique; Reverter-Masià, Joaquim
- Abstract
Purpose: The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay. Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed. Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P <.001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P =.003). Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.
- Subjects
EXERCISE physiology; INFORMATION storage &; retrieval systems; MEDLINE; META-analysis; PEPTIDE hormones; RESEARCH funding; SPORTS; SYSTEMATIC reviews; TROPONIN; DESCRIPTIVE statistics
- Publication
Pediatric Exercise Science, 2019, Vol 31, Issue 1, p28
- ISSN
0899-8493
- Publication type
Article
- DOI
10.1123/pes.2018-0058