We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Back Cover: Conformational Analysis of an Antibacterial Cyclodepsipeptide Active against Mycobacterium tuberculosis by a Combined ROE and RDC Analysis (Chem. Eur. J. 24/2017).
- Authors
Fredersdorf, Maic; Kurz, Michael; Bauer, Armin; Ebert, Marc‐Olivier; Rigling, Carla; Lannes, Laurie; Thiele, Christina Marie
- Abstract
Griselimycin (GM) and methylgriselimycin (MGM) are cyclic depsipeptides that inhibit the sliding clamp of DNA polymerase III of Mycobacterium tuberculosis and are therefore considered as potential anti‐tuberculosis drugs. Methylation increases both stability and activity of MGM compared to GM. The solution structure of MGM was determined using advanced NMR spectroscopy. A highly defined structural model of MGM was obtained, which shows related characteristics to GM bound to DNA polymerase III subunit‐beta. More information can be found in the Full Paper by C. M. Thiele et al. on page 5729 ff.
- Subjects
CONFORMATIONAL analysis; ANTIBACTERIAL agents; DEPSIPEPTIDES
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 24, p5854
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201700694