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- Title
Development of a Dual-Modally Traceable Nanoplatform for Cancer Theranostics Using Natural Circulating Cell-Derived Microparticles in Oral Cancer Patients.
- Authors
Yu, Zi‐Li; Zhang, Wei; Zhao, Jing‐Ya; Zhong, Wen‐Qun; Ren, Jian‐Gang; Wu, Min; Zhang, Zhi‐Ling; Pang, Dai‐Wen; Zhao, Yi‐Fang; Chen, Gang
- Abstract
Cell-derived microparticles (MPs), which are biogenic nanosized membrane vesicles that convey bioactive molecules between cells, have exhibited great potential to serve as therapeutic platforms. However, so far, all the MPs used as theranostic vectors in previous studies have been produced in vitro from cell culture supernatants, which is still associated with several concerns regarding practical applications. In this study, circulating MPs (CMPs), which are freshly purified from the peripheral blood of oral squamous cell carcinoma (OSCC) patients, are directly and efficiently embedded with ultrasmall near-infrared-fluorescent magnetic quantum dots (Ag2Se@Mn QDs) via electroporation. By virtue of the superior photostability, favorable biocompatibility, and dual-mode traceability of Ag2Se@Mn QD-labeled CMPs in vivo, the tissue distribution and natural tumor-targeting behavior of CMPs from OSCC patients are directly visualized in living mice for the first time. Moreover, by simultaneously embedding antitumor siRNA and Ag2Se@Mn QDs into CMPs derived from OSCC patients, a dual-modally traceable and actively tumor-targeted nanoplatform for cancer theranostics is developed. This study reports the first reliable conjugation-free labeling strategy for in vivo dual-mode tracking of CMPs harvested from the human body, and, more importantly, reports the development of traceable tumor-targeted theranostic vectors based on naturally occurring CMPs from cancer patients.
- Subjects
ORAL cancer diagnosis; COMPANION diagnostics; ORAL cancer patients; CANCER cells; NANOPARTICLES
- Publication
Advanced Functional Materials, 2017, Vol 27, Issue 40, pn/a
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201703482