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- Title
Maternal history of childhood maltreatment is associated with diurnal cortisol and DNA methylation of placental 11-beta-hydroxysteroid dehydrogenase type 2.
- Authors
Bublitz, Margaret; Kelsey, Karl; Butler, Rondi; Bourjeily, Ghada
- Abstract
Background: Accumulating evidence indicates that maternal hypothalamic-pituitary-adrenal (HPA) axis activity over pregnancy differs according to maternal history of childhood maltreatment. DNA methylation of the placental 11-beta-hydroxysteroid dehydrogenase (BHSD) type 2 enzyme regulates fetal exposure to maternal cortisol, yet the association between maternal history of childhood maltreatment and methylation of placental 11BHSD type 2 has not been previously studied. Methods: We examined if maternal cortisol production at 11 and 32 weeks' gestation (n = 89) and placental methylation of the 11BHSD type 2 gene (n = 19) differed among pregnant women with and without histories of childhood maltreatment. Twenty-nine percent of participants reported a history of childhood maltreatment (physical/sexual abuse). Results: Women with histories of childhood maltreatment displayed lower cortisol in early gestation, hypo-methylation of placental 11BHSD type 2, and lower levels of cord blood cortisol. Conclusion: Preliminary results suggest alterations in cortisol regulation over pregnancy according to maternal history of childhood maltreatment.
- Subjects
ADVERSE childhood experiences; OBESITY; CHILD sexual abuse; ANALYSIS of variance; ASSAULT &; battery; SALIVA; SELF-perception; FLUOROIMMUNOASSAY; PREGNANT women; GESTATIONAL age; DNA methylation; HYPOTHALAMIC-pituitary-adrenal axis; CORDOCENTESIS; PARENTING; CRONBACH'S alpha; SEVERITY of illness index; T-test (Statistics); PLACENTA; QUESTIONNAIRES; MENTAL depression; SLEEP apnea syndromes; RESEARCH funding; OXIDOREDUCTASES; STATISTICAL sampling; DATA analysis software; HYDROCORTISONE; PSYCHOLOGICAL stress; DISEASE risk factors; PREGNANCY
- Publication
Obstetric Medicine (1753-495X), 2023, Vol 16, Issue 1, p12
- ISSN
1753-495X
- Publication type
Article
- DOI
10.1177/1753495X221087168