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- Title
The Yonsei criteria as a clinically detectable parameter for excellent prognosis in resected left-sided pancreatic cancer: outcomes of a propensity score-matched analysis.
- Authors
Lee, Sung; Hwang, Ho; Kang, Chang; Lee, Woo; Lee, Sung Hwan; Hwang, Ho Kyoung; Kang, Chang Moo; Lee, Woo Jung
- Abstract
<bold>Background: </bold>This study aimed to identify that Yonsei criteria (YC) can be regarded as a preoperative clinical parameter to predict biological behavior of the left-sided pancreatic cancer.<bold>Methods: </bold>Between June 2007 and December 2014, 135 patients who underwent minimally invasive (MIS) or open distal pancreatectomy for left-sided pancreatic cancer were enrolled in this study consecutively. Perioperative short-term and long-term oncologic outcomes were analyzed according to the YC retrospectively.<bold>Results: </bold>Fifty-four and 81 patients did and did not meet the YC, respectively. Short-term oncologic outcomes were favorable among those meeting the YC even after propensity score matching. Patients within the YC also had better disease-free and disease-specific overall survival (p < 0.05). In analysis for receiver operating characteristic curve, area under curve of CA19-9 was satisfactory only within YC group. Multivariate analysis for disease-free survival identified the YC as a strong independent prognostic factor (p < 0.05). In preoperative clinical setting, patients' survival was clearly different based on following clinical groups, such as within YC, beyond YC, and unresectable.<bold>Conclusions: </bold>Preoperative CT-based determined YC can predict excellent short-term and long-term oncologic outcomes. YC might have a potential role as a preoperative clinical staging for left-sided pancreatic cancer. External validations of YC based on multicenter cohorts are mandatory to confirm this oncologic significance of YC.
- Subjects
PANCREATIC cancer; PANCREATECTOMY; PREOPERATIVE care; PANCREATIC cancer treatment; ENDOSCOPIC surgery; HEALTH outcome assessment; PROGNOSIS; PANCREATIC surgery; CANCER relapse; LONGITUDINAL method; PANCREAS; PANCREATIC tumors; PROBABILITY theory; SURVIVAL; TREATMENT effectiveness; PROPORTIONAL hazards models; RETROSPECTIVE studies; PATIENT selection; RECEIVER operating characteristic curves
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2017, Vol 31, Issue 11, p4656
- ISSN
1866-6817
- Publication type
journal article
- DOI
10.1007/s00464-017-5529-6