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- Title
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.
- Authors
Pasquinelli, Amy E.; Reinhart, Brenda J.; Slack, Frank; Martindale, Mark Q.; Kuroda, Mitzi I.; Maller, Betsy; Hayward, David C.; Ball, Eldon E.; Degnan, Bernard; Muller, Peter; Spring, Jurg; Srinivasan, Ashok; Fishman, Mark; Finnerty, John; Corbo, Joseph; Levine, Michael; Leahy, Patrick; Davidson, Eric; Ruvkun, Gary
- Abstract
Presents findings related to the role of the lin-4 and let-7 RNA genes. Detection of let-7 RNA of ~21 nucleotides in samples from a wide variety of animal species, but not in RNA from several cnidarian and poriferan species; Lack of lin-4 RNA in the species that contained let-7; Expression of let-7 RNA in Caenorhabditis elegans and Drosophila; Conclusion that the let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny.
- Subjects
GENETIC regulation; RNA; GENES; DEVELOPMENTAL genetics
- Publication
Nature, 2000, Vol 408, Issue 6808, p86
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35040556