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- Title
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
- Authors
Iwasaki, Naruhito; Terawaki, Seigo; Shimizu, Kouhei; Oikawa, Daisuke; Sakamoto, Hirokazu; Sunami, Kishiko; Tokunaga, Fuminori
- Abstract
Objective: Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders. Methods: The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model. Results: Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure. Conclusion: These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.
- Subjects
HISTAMINE; TH2 cells; T cell receptors; TH1 cells; T cells
- Publication
Inflammation Research, 2021, Vol 70, Issue 5, p539
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-021-01458-x