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- Title
Association of promoter region single nucleotide polymorphisms at positions −819C/T and −592C/A of interleukin 10 gene with ischemic heart disease.
- Authors
Yu, Gyeong-Im; Cho, Ho-Chan; Cho, Yun-Kyeong; Park, Hyoung-Seob; Yoon, Hyuck-Jun; Kim, Hyung-Seop; Nam, Chang-Wook; Kim, Yoon-Nyun; Kim, Kwon-Bae; Ha, Eunyoung; Shin, Dong-Hoon; Hur, Seung-Ho
- Abstract
Objective: Ischemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD. Methods: We recruited 313 control and 173 IHD patients. The selected SNPs in IL10 were genotyped using pyrosequencing. Results: SNPs at positions −592C/A and −819C/T were statistically associated with IHD ( P = 0.014 and P = 0.037). Similarly, the mean value of C-reactive protein in the C allele at −592C/A and −819C/T was significantly higher than that in the A allele at −592C/A ( P = 0.026) and T allele at −819C/T ( P = 0.026). The presence of hypertension in the C allele at −592C/A and −819C/T was significantly more frequent than that in the A allele at −592C/A ( P = 0.044) and T allele at −819C/T ( P = 0.044). In the haplotype of two SNPs (−592C/A and −819C/T), one haplotype (CC) presented an association with IHD ( P = 0.012). Conclusions: These results indicate that the C allele with SNPs at position −592C/A and −819C/T of IL10 gene may be associated with IHD in the Korean population.
- Subjects
GENETIC polymorphisms; PROMOTERS (Genetics); CORONARY disease; INTERLEUKIN-10; SINGLE nucleotide polymorphisms
- Publication
Inflammation Research, 2012, Vol 61, Issue 8, p899
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-012-0482-2