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- Title
Serotoninový syndrom a léčba bolesti.
- Authors
Procházka, Jan
- Abstract
Serotonin syndrome is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral and central nervous systems. It is characterized by a broad spectrum of clinical findings, which include mental state changes, autonomic instability, and hyperexcitability of CNS with neuromuscular abnormalities. Serotonin syndrome can arise usually by simultaneous administrations of 2 or more serotoninergic drugs, the combination including monoamine oxidase inhibitors is especially dangerous, but occurrence in monotherapy is also possible. This review describes pathophysiology and clinical manifestation of this syndrome and the drugs at risk, with a particular focus on drugs used in the treatment of chronic pain.
- Publication
Neurologie Pro Praxi, 2024, Vol 25, Issue 2, p135
- ISSN
1213-1814
- Publication type
Article
- DOI
10.36290/neu.2023.052