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- Title
The Role of Glucocorticoids in the Treatment of Multisystem Inflammatory Syndrome (MIS-C)—Data from POLISH MIS-C Registry.
- Authors
Gowin, Ewelina; Toczyłowski, Kacper; Sulik, Artur; Wysocki, Jacek; Januszkiewicz-Lewandowska, Danuta
- Abstract
Background: Multisystem inflammatory syndrome (MIS-C) is a condition related to COVID-19. It's most significant feature is cardiac involvement. Methods: We have analyzed data from 42 hospitals in the Polish MIS-C Registry. To compare the effect of GCS on fever, we formed two groups: the first treated with IVIG and the second treated with IVIG+GCS. Results: There were 111 boys and 56 girls; the mean age was 8.57 years. All the patients were treated with IVIG: 76 patients with IVIG only, and 91 patients with IVIG+GCS. There were no statistically significant differences between the groups regarding age, gender, BMI, or inflammatory markers. Methylprednisolone was the most common drug (80%). Echocardiographic abnormalities on admission were more prevalent in the IVIG+GCS group. Mean time from IVIG infusion to subsidence of fever was 1.1 days, and 1.5 for those in the IVIG+GCS group. Conclusions: GCS are commonly used in the treatment of MIS-C patients in Poland. Various GCS regimens are used, from a single dose to a month-long therapy. Children with lower lymphocyte levels and cardiac abnormalities on an echocardiographic examination performed on admission were more likely to receive GCS+IVIG. The effect of GCS is difficult to access as patients were not randomly assigned to receive the treatment.
- Subjects
POLAND; THERAPEUTIC use of immunoglobulins; THERAPEUTIC use of glucocorticoids; DRUG efficacy; METHYLPREDNISOLONE; MULTISYSTEM inflammatory syndrome; COVID-19; FEVER; COMBINATION drug therapy; ANTI-inflammatory agents; PEDIATRICS; COMPARATIVE studies; DISEASE duration; DESCRIPTIVE statistics; EVALUATION; CHILDREN; ADOLESCENCE
- Publication
Children, 2022, Vol 9, Issue 2, p178
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children9020178