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- Title
Association between pre-donation serum uric acid concentration and change in renal function after living kidney donation in women.
- Authors
Cho, A.; Lee, J. E.; Jang, H. R.; Huh, W.; Kim, D. J.; Oh, H. Y.; Kim, Y.‐G.
- Abstract
Background Reduction in renal mass after unilateral nephrectomy causes functional and structural changes in the remaining kidney. Aim We aimed to investigate the association between pre-donation serum uric acid ( SUA) concentration and the change in renal function after living kidney donation. Methods This retrospective study included 413 living kidney donors from a single centre. We collected medical history and laboratory findings at baseline and 6 months after donation. Renal function was assessed by calculating the estimated glomerular filtration rate ( eGFR) using the Chronic Kidney Disease Epidemiology Collaboration equation. Main outcomes were the percentage change in eGFR from before to 6 months after donation and the percentage of patients whose eGFR decreased by >25% after donation compared with the pre-donation baseline value. Results Mean age was 40 ± 11 years, and eGFR was 106 ± 14 mL/min/1.73 m2. In women, the SUA concentration was linearly associated with the change in eGFR after donation independently of baseline eGFR (standardised coefficient - 0.16, P = 0.04). Multiple logistic analysis showed that a 59.5 μmol/L increase in baseline SUA concentration was associated with a 1.7-fold higher risk of a > 25% decrease in eGFR after donor nephrectomy (95% confidence interval, 1.2-2.5; P = 0.007) in women. In contrast, SUA concentration was not an independent risk factor of decrease in eGFR after donor nephrectomy in men. Conclusions Pre-donation SUA concentration is associated independently with the change in renal function after donor nephrectomy in women but not in men.
- Subjects
KIDNEY transplantation; KIDNEY disease diagnosis; KIDNEY physiology; KIDNEYS; ANALYSIS of variance; BLOOD pressure; BLOOD pressure measurement; CHOLESTEROL; GLOMERULAR filtration rate; INTERNAL medicine; EVALUATION of medical care; ORGAN donors; SERIAL publications; URIC acid; DATA analysis; BODY mass index; RETROSPECTIVE studies; DESCRIPTIVE statistics; ANATOMY
- Publication
Internal Medicine Journal, 2014, Vol 44, Issue 12a, p1217
- ISSN
1444-0903
- Publication type
Article
- DOI
10.1111/imj.12591