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- Title
Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report.
- Authors
Garcia, Angelica; Yi, Nam‐Joon; Lee, Kyoung Bun; Lee, Jeong‐Moo; Choi, Young Rok; Suh, Suk‐Won; You, Tae; Lee, Kwang‐Woong; Park, June Dong; Kang, Hyoung Jin; Kim, Joon Gon; Kang, Eun Kyeong; Hong, Geun; Suh, Kyung‐Suk
- Abstract
Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.
- Subjects
DAPSONE; ALLERGIES; LIVER transplantation; HEPATITIS; MULTIPLE organ failure; DRUG allergy
- Publication
Pediatric Transplantation, 2014, Vol 18, Issue 7, pE240
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.12343