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- Title
Meta-analysis of COVID-19 single-cell studies confirms eight key immune responses.
- Authors
Garg, Manik; Li, Xu; Moreno, Pablo; Papatheodorou, Irene; Shu, Yuelong; Brazma, Alvis; Miao, Zhichao
- Abstract
Several single-cell RNA sequencing (scRNA-seq) studies analyzing immune response to COVID-19 infection have been recently published. Most of these studies have small sample sizes, which limits the conclusions that can be made with high confidence. By re-analyzing these data in a standardized manner, we validated 8 of the 20 published results across multiple datasets. In particular, we found a consistent decrease in T-cells with increasing COVID-19 infection severity, upregulation of type I Interferon signal pathways, presence of expanded B-cell clones in COVID-19 patients but no consistent trend in T-cell clonal expansion. Overall, our results show that the conclusions drawn from scRNA-seq data analysis of small cohorts of COVID-19 patients need to be treated with some caution.
- Subjects
COVID-19; COVID-19 pandemic; TYPE I interferons; IMMUNE response; CELLULAR signal transduction
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-00121-z