We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains.
- Authors
Hayashi, Kazuhiko; Katano, Yoshiaki; Ishigami, Masatoshi; Itoh, Akihiro; Hirooka, Yoshiki; Nakano, Isao; Yoshioka, Kentaro; Yano, Motoyoshi; Toyoda, Hidenori; Kumada, Takashi; Goto, Hidemi
- Abstract
Background and Aims: Acute hepatitis caused by lamivudine (LMV)-resistant strains has not been reported, and the clinical impact of LMV-resistant strains on acute hepatitis is not known. The aim of this study was to investigate the molecular and clinical characteristics of patients with acute hepatitis B caused by LMV-resistant strains. Methods: Forty-five patients with acute hepatitis B were studied. Hepatitis B virus (HBV) subgenotypes and LMV-resistance mutations were determined by direct sequencing of the preS and polymerase regions, respectively. Results: HBV subgenotypes A2 ( n = 18), B1 ( n = 1), B2 ( n = 3), B3 ( n = 2), C1 ( n = 1), C2 ( n = 19) and C6 ( n = 1) were detected in patients with acute hepatitis. LMV-resistance mutations were detected in two patients. LMV-resistance mutations (L180M, M204I) were detected in a patient with subgenotype C2 who had acute self-limited hepatitis. The other patient with LMV-resistance mutations (L180M, M204V) was infected with subgenotype A2 and had severe hepatitis. Conclusion: LMV-resistant strains are rare, but they are starting to be found in patients with acute hepatitis B. Surveillance for detecting drug-resistant HBV strains would be important for clinical practice.
- Subjects
HEPATITIS B; DISEASE prevalence; LAMIVUDINE; HEPATITIS; NUCLEOTIDE sequence; POLYMERASE chain reaction; PATIENTS
- Publication
Journal of Gastroenterology & Hepatology, 2010, Vol 25, Issue 4, p745
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2009.06118.x