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- Title
A Possible Correlation between Interferon-stimulated Gene Expression and Cytogenetic Responses in Chronic Myelogenous Leukemia Patients Treated with α-interferon.
- Authors
Kawakubo, Ken; Ohyashiki, Kazuma; Ohyashiki, Junko H.; Shimamoto, Takashi; Fujimura, Toshikatsu; Iwama, Hiroshi; Toyama, Keisuke
- Abstract
We studied the expression of the interferon-stimulated genes (ISGs), ISG-54 and 2′, 5′-oligoadenylate synthetase (2′-5′ OAS), using the reverse transcription-polymerase chain reaction in 22 patients with chronic myelogenous leukemia (CML), who were treated with ainterferon (α-IFN). At the time of diagnosis, 7 patients (31.8%) showed no detectable expression of either gene, whereas 8 expressed both. The remaining 7 expressed neither ISG-54 nor 2′-5′ OAS. After a-IFN treatment, 5 of the 7 CML patients who had not previously expressed ISGs expressed either ISG-54 or 2′-5′ OAS or both and 6 of the 7 who had previously expressed either ISG-54 or 2′-5′ OAS expressed both. Three of the 7 (42.9%) CML patients who expressed both genes before and after α-IFN administration showed cytogenetic responses, as did 6 of the 11 (54.5%) in whom ISG expression was induced. In contrast, cytogenetic responses occurred in none of the patients in whom ISG expression was not induced. These results suggest that induction of ISG-54 and 2′-5′ OAS expression by α-IFN may be an indicator of cytogenetic responses and, therefore, of value for monitoring CML patients.
- Publication
Japanese Journal of Clinical Oncology, 1996, Vol 26, Issue 2, p59
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/oxfordjournals.jjco.a023185