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- Title
Long-Term Outcomes of Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia.
- Authors
Kwon, Hye Won; Kim, Han-Suk; An, Hyo Soon; Kwon, Bo Sang; Kim, Gi Beom; Shin, Seung Han; Kim, Ee-Kyung; Bae, Eun Jung; Noh, Chung Il; Choi, Jung-Hwan
- Abstract
Background: The long-term cardiovascular outcomes of pulmonary hypertension (PH) in preterm infants with bronchopulmonary dysplasia (BPD) are uncertain. Objectives: The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. Methods: We retrospectively reviewed the medical records of patients born before 32 weeks of gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008. Patients were recruited for a cross-sectional study from August to October 2014 and underwent echocardiography. Results: Forty-two children were enrolled. Their mean gestational age and birth weight were 26.2 ± 1.7 weeks and 753.1 ± 172.5 g, respectively. Sixteen patients (38%) were diagnosed with PH at a mean age of 3.3 ± 1.6 months, and the PH improved after a median of 12.3 months (range 0.7-46.6). Cardiovascular function was reassessed at a mean age of 7.7 ± 0.9 years, at which time 1 patient was taking a medication for recurrent PH, and 12 (28.6%) patients exhibited elevated blood pressure. Conventional 2-dimensional and Doppler echocardiography indicated normal ventricular function in all children. However, right ventricular longitudinal strains were decreased in children with previous PH. Conclusions: Subclinical ventricular dysfunction was detectable using sensitive echocardiographic techniques in children with previous BPD-associated PH. Long-term follow-up and meticulous cardiovascular function assessment are required in this population.
- Subjects
BRONCHOPULMONARY dysplasia; PULMONARY hypertension; PREMATURE infant diseases; HEALTH outcome assessment; HEART failure in children; ECHOCARDIOGRAPHY; HYPERTENSION risk factors
- Publication
Neonatology (16617800), 2016, Vol 110, Issue 3, p181
- ISSN
1661-7800
- Publication type
Article
- DOI
10.1159/000445476