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- Title
Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis.
- Authors
Fitzsimmons, Tracy R.; Sanders, Anne E.; Bartold, P. Mark; Slade, Gary D.
- Abstract
Aim: To determine the independent and combined associations of interleukin-1 β (IL-1 β) and C-reactive protein (CRP) in gingival crevicular fluid (GCF) on periodontitis case status in the Australian population. Materials and Methods: GCF was collected from 939 subjects selected from the 2004–2006 Australian National Survey of Adult Oral Health: 430 cases had examiner-diagnosed periodontitis, and 509 controls did not. IL-1 β and CRP in GCF were detected by enzyme-linked immunosorbent assays. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated in bivariate and stratified analysis and fully adjusted ORs were estimated using multivariate logistic regression. Results: Greater odds of having periodontitis was associated with higher amounts of IL-1 β (OR=2.4, 95% CI=1.7–3.4 for highest tertile of IL-1 β relative to lowest tertile) and CRP (OR=1.9, 95% CI=1.5–2.5 for detectable CRP relative to undetectable CRP). In stratified analysis, there was no significant interaction between biomarkers ( p=0.68). In the multivariate analyses that controlled for conventional periodontal risk factors, these relationships remained (IL-1 β OR=1.8, 95% CI=1.1–2.6; CRP OR=1.7, 95% CI=1.3–2.3). Conclusions: Elevated odds of clinical periodontitis was associated independently with each biomarker. This suggests that people with elevated biomarkers indicative of either local (IL-1 β) or systemic (CRP) inflammation are more likely to suffer from periodontal disease.
- Subjects
BIOMARKERS; INFLAMMATION; C-reactive protein; ENZYME-linked immunosorbent assay; INTERLEUKIN-1
- Publication
Journal of Clinical Periodontology, 2010, Vol 37, Issue 1, p30
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/j.1600-051X.2009.01506.x