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- Title
Clinicopathological features, treatment modalities, and prognosis of esophageal neuroendocrine carcinoma: A single‐center retrospective study.
- Authors
Zhang, Yao; Liao, Jiao Tao; Lin, Ying; Liu, Chang; Wu, Zhen Hua; Yu, Bo; Sun, Si; Yu, Hui; Hui, Xiao Hua; Wu, Xiang Hua; Zhao, Xin Min; Wang, Hui Jie; Zheng, Qiang; Li, Yuan; Hu, Zhi Huang; Wang, Jia Lei
- Abstract
Objectives: Esophageal neuroendocrine carcinoma (ENEC) is a rare cancer that is highly malignant and related to a poor prognosis. In this retrospective study we aimed to elucidate the clinical characteristics, diagnosis and management of patients with ENEC and to evaluate the potential prognostic factors. Methods: Altogether 82 patients diagnosed with ENEC between January 2009 and December 2020 at the Fudan University Shanghai Cancer Center were retrospectively enrolled. Patients' survival was analyzed using the Kaplan–Meier and log‐rank methods. Univariate and multivariate analyses and a Cox regression model were used to identify the prognostic factors. Results: The median overall survival (mOS) was 13 months in all patients. Multivariate analysis revealed that advanced tumor stage (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.07–6.66, P = 0.0353), liver (HR 3.36, 95% CI 1.53–7.41, P = 0.0026) and lung metastasis (HR 3.37, 95% CI 1.20–9.51, P = 0.0214) were associated with a poor prognosis. While positive chromogranin A (CgA) expression was related to a favorable outcome (HR 0.21, 95% CI 0.09–0.49, P < 0.001). Also, patients had adjustment of chemotherapy (dose reduction or less than three cycles) were prone to a worse prognosis compared with those did not (HR 4.36, 95% CI 2.10–9.08, P < 0.001). Conclusion: In patients with ENEC, advanced cancer stage, adjustment of chemotherapy, liver and lung metastasis were associated with a poor survival, while CgA expression was related to a favorable prognosis.
- Subjects
FUDAN University (Shanghai, China); NEUROENDOCRINE tumors; SURVIVAL analysis (Biometry); REGRESSION analysis; OVERALL survival; PROGNOSIS; MERKEL cell carcinoma
- Publication
Journal of Digestive Diseases, 2023, Vol 24, Issue 8/9, p472
- ISSN
1751-2972
- Publication type
Article
- DOI
10.1111/1751-2980.13219