We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Long-term evaluation of basiliximab induction therapy in live donor kidney transplantation: a five-year prospective randomized study.
- Authors
Sheashaa, Hussein A.; Bakr, Mohamed A.; Ismail, Amany M.; Gheith, Osama E.; El-dahshan, Khalid F.; Sobh, Mohamed A.; Ghoneim, Mohamed A.
- Abstract
<bold>Background/aims: </bold>The long-term evaluation of basiliximab induction therapy has not been addressed yet. We aim to evaluate its long-term effects in living related donor kidney transplantation.<bold>Methods: </bold>100 adult recipients with their first kidney allograft were randomized into two treatment groups--one group received basiliximab and the second served as a control. All patients received a maintenance triple immunosuppressive therapy (steroids, cyclosporine microemulsion and azathioprine) and were closely followed for 5 years.<bold>Results: </bold>Basiliximab significantly reduced the proportion of patients who experienced an acute rejection in the first year (18/50) when compared to the control group (31/50) and in 5 years (27/50) when compared to (36/50) the controls. The cumulative steroid dose used throughout the study was significantly lower in the basiliximab group. The overall incidence of post-transplant complications was comparable between the two treatment groups. There was no significant difference in patients and graft survival; 5-year patient and graft survival were 100 and 86% for basiliximab, and 96 and 88% for the control group respectively.<bold>Conclusion: </bold>Although routine basiliximab induction significantly reduces the incidence of acute rejection, its beneficial long-term effects on graft function and patient and graft survival are not yet evident.
- Subjects
KIDNEY transplantation; ORGAN donors; CLINICAL trials; DRUG therapy; DRUGS
- Publication
American Journal of Nephrology, 2005, Vol 25, Issue 3, p221
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000085892