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- Title
Impaired oxygen kinetics in beta-thalassaemia major patients.
- Authors
Vasileiadis, I.; Roditis, P.; Dimopoulos, S.; Ladis, V.; Pangalis, G.; Aessopos, A.; Nanas, S.
- Abstract
Aim: Beta-thalassaemia major (TM) affects oxygen flow and utilization and reduces patients’ exercise capacity. The aim of this study was to assess phase I and phase II oxygen kinetics during submaximal exercise test in thalassaemics and make possible considerations about the pathophysiology of the energy-producing mechanisms and their expected exercise limitation. Methods: Twelve TM patients with no clinical evidence of cardiac or respiratory disease and 10 healthy subjects performed incremental, symptom-limited cardiopulmonary exercise testing (CPET) and submaximal, constant workload CPET. Oxygen uptake ( Vo2), carbon dioxide output and ventilation were measured breath-by-breath. Results: Peak Vo2 was reduced in TM patients (22.3 ± 7.4 vs. 28.8 ± 4.8 mL kg−1 min−1, P < 0.05) as was anaerobic threshold (13.1 ± 2.7 vs. 17.4 ± 2.6 mL kg−1 min−1, P = 0.002). There was no difference in oxygen cost of work at peak exercise (11.7 ± 1.9 vs. 12.6 ± 1.9 mL min−1 W−1 for patients and controls respectively, P = ns). Phase I duration was similar in TM patients and controls (24.6 ± 7.3 vs. 23.3 ± 6.6 s respectively, P = ns) whereas phase II time constant in patients was significantly prolonged (42.8 ± 12.0 vs. 32.0 ± 9.8 s, P < 0.05). Conclusion: TM patients present prolonged phase II on-transient oxygen kinetics during submaximal, constant workload exercise, compared with healthy controls, possibly suggesting a slower rate of high energy phosphate production and utilization and reduced oxidative capacity of myocytes; the latter could also account for their significantly limited exercise tolerance.
- Subjects
OXYGEN; OXYGEN therapy; RESPIRATORY therapy; MUSCLE cells; LUNG diseases; PULMONARY circulation
- Publication
Acta Physiologica, 2009, Vol 196, Issue 3, p357
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/j.1748-1716.2008.01937.x