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- Title
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum.
- Authors
Yamashita, Toru; Ninomiya, Mikiko; Acosta, Pilar Hernández; García-Verdugo, Jose Manuel; Sunabori, Takehiko; Sakaguchi, Masanori; Adachi, Kazuhide; Kojima, Takuro; Hirota, Yuki; Kawase, Takeshi; Araki, Nobuo; Abe, Koji; Okano, Hideyuki; Sawamoto, Kazunobu
- Abstract
Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.
- Subjects
NEURONS; DEVELOPMENTAL neurobiology; GENE expression; BRAIN; CELLS
- Publication
Journal of Neuroscience, 2006, Vol 26, Issue 24, p27
- ISSN
0270-6474
- Publication type
Abstract
- DOI
10.1523/JNEUROSCI.0149-06.2006