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- Title
Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model.
- Authors
Alkhalil, Abdulnaser; Ball, Robert L; Garg, Gaurav; Day, Anna; Carney, Bonnie C; Kumar, Raina; Hammamieh, Rasha; Moffatt, Lauren T; Shupp, Jeffrey W
- Abstract
As the field of metabolomics develops further, investigations of how the metabolome is affected following thermal injury may be helpful to inform diagnostics and guide treatments. In this study, changes to the metabolome were tested and validated in a murine burn injury model. After a 30% total body surface scald injury or sham procedure sera and skin biopsies were collected at 1, 2, 6, or 24 hr. Burn-specific changes in the metabolome were detected compared to sham animals. The sera metabolome exhibited a more rapid response to burn injury than that of the skin and it peaked more proximal to injury (6 vs 24 hr). Progression of metabolic response in the skin was less synchronous and showed a higher overlap of the significantly modified metabolites (SMMs) among tested time-points. Top affected pathways identified by SMMs of skin included inositol phosphate metabolism, ascorbate and alderate metabolism, caffeine metabolism, and the pentose phosphate pathway. Future research is warranted in human and larger animal models to further elucidate the role of metabolomic perturbations and the pathophysiology following burn injury.
- Subjects
METABOLOMICS; PENTOSE phosphate pathway; PHOSPHATE metabolism; INOSITOL phosphates; PATHOLOGICAL physiology
- Publication
Journal of Burn Care & Research, 2021, Vol 42, Issue 4, p727
- ISSN
1559-047X
- Publication type
journal article
- DOI
10.1093/jbcr/iraa209