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- Title
Theophylline: potentiation of arginine-induced somatostatin release from the isolated rat pancreas.
- Authors
Goto, Yasuo; Seino, Yutaka; Taminato, Tomohtko; Kadowaki, Seizo; Chiba, Tsutomu; Note, Shinya; Imura, Hiroo; Goto, Y; Seino, Y; Taminato, T; Kadowaki, S; Chiba, T; Note, S; Imura, H
- Abstract
Somatostatin's release from the isolated rat pancreas was studied using a perfusion technique. Arginine at a concentration of 19 mM produced a biphasic increase in somatostatin release from the perfused rat pancreas. Both first and second phases of somatostatin's increase are significantly higher in the presence of 1 mM theophylline than in the absence of the drug. These results indicate the possible inclusion of the adenylate cyclase--cyclic AMP system in the regulatory mechanism of rat pancreatic somatostatin secretion.
- Publication
Diabetes, 1979, Vol 28, Issue 5, p457
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.28.5.457