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- Title
Brain immunohistopathological study in a patient with anti-NMDAR encephalitis.
- Authors
Camdessanché, J.-P.; Streichenberger, N.; Cavillon, G.; Rogemond, V.; Jousserand, G.; Honnorat, J.; Convers, P.; Antoine, J.-C.
- Abstract
Anti- N-methyl--asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti-NMDA receptor encephalitis. An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies. Prominent B-cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma. These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
- Subjects
IMMUNOGLOBULINS; BRAIN imaging; IMMUNOHISTOCHEMISTRY; B cells; T cells; PLASMA cells; ENCEPHALITIS; PATIENTS
- Publication
European Journal of Neurology, 2011, Vol 18, Issue 6, p929
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/j.1468-1331.2010.03180.x