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- Title
Elevated MED28 expression predicts poor outcomein women with breast cancer.
- Authors
Yoon, Nam K.; Maresh, Erin L.; Elshimali, Yahya; Ai Li; Horvath, Steve; Seligson, David B.; Chia, David; Goodglick, Lee
- Abstract
Background: MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo models. Here we examined the association of MED28 expression with human breast cancer progression. Methods: Expression of MED28 protein was determined on a population basis using a high-density tissue microarray consisting of 210 breast cancer patients. The association and validation of MED28 expression with histopathological subtypes, clinicopathological variables, and disease outcome was assessed. Results: MED28 protein expression levels were increased in ductal carcinoma in situ and invasive ductal carcinoma of the breast compared to non-malignant glandular and ductal epithelium. Moreover, MED28 was a predictor of disease outcome in both univariate and multivariate analyses with higher expression predicting a greater risk of disease-related death. Conclusions: We have demonstrated that MED28 expression is increased in breast cancer. In addition, although the patient size was limited (88 individuals with survival information) MED28 is a novel and strong independent prognostic indicator of survival for breast cancer.
- Subjects
CELL proliferation; BREAST cancer; CANCER patients; EPITHELIUM; MULTIVARIATE analysis
- Publication
BMC Cancer, 2010, Vol 10, p335
- ISSN
1471-2407
- Publication type
Article
- DOI
10.1186/1471-2407-10-335