We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Precision medicine in cats—The right biomedical model may not be the mouse!
- Authors
Lyons, Leslie A.
- Abstract
Precision medicine in cats - The right biomedical model may not be the mouse! On the best of days, using state-of-the-art genetic approaches involving whole genome and whole exome sequencing (WGS/WES), geneticist have only approximately a 50:50 chance of rapidly identifying variants causal for health and developmental abnormalities in humans [[1]]. More focus and support for genome editing in cats will help produce cat models when rodents and porcine are not appropriate. Additional support for cat genomics and genome editing could lead to effective, feline-based biomedical models that fill an important void for VUS interpretation, targeted therapeutics, and translation medicine.
- Subjects
INDIVIDUALIZED medicine; TUMOR necrosis factors; CATS; EXOMES; DEVELOPMENTAL biology; NEURONAL ceroid-lipofuscinosis
- Publication
PLoS Genetics, 2020, Vol 16, Issue 12, p1
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.1009177