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- Title
Experimental study on the mechanical interaction between silicon neural microprobes and rat dura mater during insertion.
- Authors
Fekete, Z.; Németh, A.; Márton, G.; Ulbert, I.; Pongrácz, A.
- Abstract
In vivo insertion experiments are essential to optimize novel neural implants. Our work focuses on the interaction between intact dura mater of rats and as-fabricated single-shaft silicon microprobes realized by deep reactive ion etching. Implantation parameters like penetration force and dimpling through intact dura mater were studied as a function of insertion speed, microprobe cross-section, tip angle and animal age. To reduce tissue resistance, we proposed a unique tip sharpening technique, which was also evaluated in in vivo insertion tests. By doubling the insertion speed (between 1.2 and 10.5 mm/min), an increase of 10-35 % in penetration forces was measured. When decreasing the cross-section of the microprobes, penetration forces and dimpling was reduced by as much as 30-50 % at constant insertion speeds. Force was noticed to gradually decrease by decreasing tip angles. Measured penetration forces through dura mater were reduced even down to 11 ± 3 mN compared to unsharpened (49 ± 13 mN) probes by utilizing our unique tip sharpening technique, which is very close to exerted penetration force in the case of retracted dura (5 ± 1.5 mN). Our findings imply that age remarkably alters the elasticity of intact dura mater. The decreasing stiffness of dura mater results in a significant rise in penetration force and decrease in dimpling. Our work is the first in vivo comparative study on microelectrode penetration through intact and retracted dura mater.
- Subjects
MICROPROBE analysis; DURA mater; BRAIN injuries; LABORATORY rats; CRYSTALLOGRAPHY; SCANNING electron microscopes
- Publication
Journal of Materials Science: Materials in Medicine, 2015, Vol 26, Issue 2, p1
- ISSN
0957-4530
- Publication type
Article
- DOI
10.1007/s10856-015-5401-y