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- Title
A Comprehensive Review of Natural Products as Therapeutic or Chemopreventive Agents against Head and Neck Squamous Cell Carcinoma Cells Using Preclinical Models.
- Authors
Liew, Yoon Xuan; Karen-Ng, Lee Peng; Vincent-Chong, Vui King
- Abstract
Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that arises from the epithelium lining of the oral cavity, hypopharynx, oropharynx, and larynx. Despite the advancement of current treatments, including surgery, chemotherapy, and radiotherapy, the overall survival rate of patients afflicted with HNSCC remains poor. The reasons for these poor outcomes are due to late diagnoses and patient-acquired resistance to treatment. Natural products have been extensively explored as a safer and more acceptable alternative therapy to the current treatments, with numerous studies displaying their potential against HNSCC. This review highlights preclinical studies in the past 5 years involving natural products against HNSCC and explores the signaling pathways altered by these products. This review also addresses challenges and future directions of natural products as chemotherapeutic and chemoprevention agents against HNSCC.
- Subjects
SQUAMOUS cell carcinoma; NATURAL products; ANIMAL models in research; PRODUCT reviews; NECK; LARYNGECTOMY
- Publication
Biomedicines, 2023, Vol 11, Issue 9, p2359
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11092359