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- Title
Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer's Disease.
- Authors
Koji Hori; Kimiko Konishi; Masayuki Tani; Hiroi Tomioka; Ryo Akita; Yuka Kitajima; Mari Aoki; Sachiko Yokoyama; Kazunari Azuma; Daisuke Ikuse; Norihisa Akashi; Misa Hosoi; Koichi Jinbo; Mitsugu Hachisu
- Abstract
We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer's disease or Lewy body dementia, CAA and SAA are caused by way of hyperactivity of inflammatory system and SAA is a marker of the anticholinergic burden in CNS. Taking into account the diurnal variations in the plasma levels of corticosteroids, which are thought to affect SAA, it should be measured at noon or just afterward.
- Subjects
BLOOD serum analysis; PARASYMPATHOLYTIC agents; BIOMARKERS; LEWY body dementia; INFLAMMATION
- Publication
Disease Markers, 2014, p1
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2014/459013