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- Title
PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance.
- Authors
Jie Yao; Mei Xie; Xidong Ma; Jialin Song; Yuanyong Wang; Xinying Xue
- Abstract
PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs approximately 24-31 nucleotides in length. They express in germline and somatic cells and form complexes with PIWI proteins to exert regulatory effects. New studies show that piRNAs are aberrantly expressed in various cancers. In this review, we focus on those piRNAs that are associated with cancer hallmarks such as proliferation, invasion, and chemoresistance and discuss their potential as biomarkers for cancer diagnosis and prognosis.
- Subjects
SOMATIC cells; NON-coding RNA; RNA; TUMOR markers; NUCLEOTIDES
- Publication
Frontiers in Oncology, 2022, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.965684