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- Title
Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries.
- Authors
Rhie, Mi Na; Kim, Hee Taek; Jo, Seo Young; Chu, Luan Luong; Baritugo, Kei-Anne; Baylon, Mary Grace; Lee, Jinwon; Na, Jeong-Geol; Kim, Lyul Ho; Kim, Tae Wan; Park, Chulhwan; Hong, Soon Ho; Joo, Jeong Chan; Park, Si Jae
- Abstract
The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society's dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.
- Subjects
CORYNEBACTERIUM glutamicum; KLEBSIELLA pneumoniae; CHEMICAL processes; ENGINEERING
- Publication
Biotechnology & Bioprocess Engineering, 2019, Vol 24, Issue 1, p48
- ISSN
1226-8372
- Publication type
Article
- DOI
10.1007/s12257-018-0346-x