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- Title
Traffic control on the toll road.
- Authors
Hao, Kaiyuan; Nündel, Kerstin
- Abstract
The article discusses the role of the tumor necrosis factor receptor–associated factor 3 (TRAF3) in regulating immune responses. TRAF3 is involved in signal transduction downstream of various receptors, including the tumor necrosis factor receptor superfamily and cytokine receptors. It acts as a docking platform to assemble signaling complexes and regulates the activation of different signaling pathways. TRAF3 plays a crucial role in distributing Toll-like receptor (TLR) signals to favor antiviral responses over proinflammatory pathways. It negatively regulates TLR and B cell receptor (BCR) signaling, and its deficiency leads to increased cytokine production and autoimmune diseases. The article provides new insights into how TRAF3 inhibits TLR signaling in B cells by restraining the access of positive regulators to the TLR-MyD88 complex. The findings highlight the complex and pathway-dependent functions of TRAF3 and the need for further research to understand its role in immune responses.
- Subjects
DIFFUSE large B-cell lymphomas; TUMOR necrosis factor receptors; B cell receptors; TUMOR necrosis factors; B cells; AUTOIMMUNE diseases; IMMUNOGLOBULIN M
- Publication
Journal of Leukocyte Biology, 2024, Vol 116, Issue 2, p207
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1093/jleuko/qiae129