We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.
- Authors
Lippitsch, Anne; Baal, Nelli; Chukovetskyi, Yuri; Cunningham, Sarah; Michel, Gabriela; Dietert, Kristina; Gurtner, Corinne; Gruber, Achim D; Bein, Gregor; Hackstein, Holger
- Abstract
Plasmacytoid dendritic cells (pDC) are critical to antiviral defense because of their high production of type I IFNs; less is known regarding their functions in bacterial infection. Moreover, pDC are involved in immunomodulation. A stable pool of regulatory T cells (Treg) is crucial for maintaining immune homeostasis. However, interactions between pDC and Treg regarding the regulation of Treg homeostasis are understudied. By using BDCA2‐DTR mice as a systemic pDC depletion model, we identified increased steady‐state numbers of FoxP3+ T cells with an effector Treg‐like phenotype in lungs, liver, and spleen tissues. During sublethal, pulmonary Klebsiella pneumoniae infection, pDC deficiency also elevated respiratory FoxP3+ T cell numbers. Additionally, the improvement in acute pneumonia survival until day 5 post infection was accompanied by impaired proinflammatory cytokine production. In contrast, pDC‐depleted mice exhibited a delayed clinical recovery during the post‐acute phase. Therefore, we assume that pDC act as immunomodulators supporting the rapid onset of immune response in a proinflammatory manner and regulate inflammation or tissue regeneration in the post‐acute phase. In summary, pDC assist in FoxP3+ T cell homeostasis and the regulation of Klebsiella‐pneumonia progression.
- Subjects
T cells; SUPPRESSOR cells; DENDRITIC cells; CELLULAR control mechanisms; HOMEOSTASIS
- Publication
Journal of Leukocyte Biology, 2019, Vol 106, Issue 4, p977
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1002/JLB.3AB0119-014RR