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- Title
Prognosis, risk stratification, and management of asymptomatic individuals with Brugada syndrome: A systematic review.
- Authors
Letsas, Konstantinos P.; Asvestas, Dimitrios; Baranchuk, Adrian; Liu, Tong; Georgopoulos, Stamatis; Efremidis, Michael; Korantzopoulos, Panagiotis; Bazoukis, George; Tse, Gary; Sideris, Antonios; Takagi, Masahiko; Ehrlich, Joachim R.
- Abstract
Brugada syndrome (BrS) is a primary electrical disease associated with increased risk of sudden cardiac death due to polymorphic ventricular arrhythmias. The prognosis, risk stratification, and management of asymptomatic individuals remain the most controversial issues in BrS. Furthermore, the decision to manage asymptomatic patients with an implantable cardioverter-defibrillator should be made after weighing the potential individual risk of future arrhythmic events against the risk of complications associated with the implant and follow-up of patients living with such devices, and the accompanying impairment of the quality of life. Several clinical, electrocardiographic, and electrophysiological markers have been proposed for risk stratification of subjects with BrS phenotype, but the majority have not yet been tested in a prospective manner in asymptomatic individuals. Recent data suggest that current risk factors are insufficient and cannot accurately predict sudden cardiac death events in this setting. This systematic review aims to discuss contemporary data regarding prognosis, risk stratification, and management of asymptomatic individuals with diagnosis of Brugada electrocardiogram pattern and to delineate the therapeutic approach in such cases.
- Subjects
CARDIAC arrest; ELECTROPHYSIOLOGY; IMPLANTABLE cardioverter-defibrillators; RISK assessment; PHENOTYPES; SYSTEMATIC reviews; DISEASE management; BRUGADA syndrome; VENTRICULAR arrhythmia
- Publication
Pacing & Clinical Electrophysiology, 2017, Vol 40, Issue 12, p1332
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/pace.13214