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- Title
CD36 and macrophages in atherosclerosis
- Authors
Collot-Teixeira, Sophie; Martin, Juliette; McDermott-Roe, Chris; Poston, Robin; McGregor, John Louis
- Abstract
Abstract: CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.
- Subjects
MACROPHAGES; ATHEROSCLEROSIS; MONOCYTES; BLOOD platelets
- Publication
Cardiovascular Research, 2007, Vol 75, Issue 3, p468
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1016/j.cardiores.2007.03.010